Intracranial metastasis of neuroblastoma (IMN) is associated with poor survival. No curative therapy for the treatment of IMN\r\ncurrently exists. Unfractionated radiotherapy may be beneficial in the treatment of IMN given the known radiosensitivity of\r\nneuroblastoma as well as its proclivity to metastasize as discrete lesions. We present two patients with IMN treated with Gamma\r\nKnife stereotactic radiosurgery (SRS). Single-fraction radiotherapy yielded temporary reduction of tumor burden and stability of\r\ndisease in both patients. SRS may be a useful palliative tool in the treatment of IMN and expands the overall treatment options for\r\nthis disease.
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